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Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Do not stop using Prednisolone suddenly, or you could have unpleasant withdrawal symptoms. Prednisolone is a corticosteroid medicine.