Prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Prednisone is inactive in the body. Prednisone is the most commonly-prescribed oral corticosteroid. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Prednisone to Prednisolone is impaired. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. If you have a fungal infection anywhere in your body.