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Propranolol is a competitive antagonist which specifically competes with beta-adrenergic receptor stimulating agents for available beta-receptor sites. Inderal is usually used in combination with clonidine to lower blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. Beta-blockers. Propranolol can, in certain patients, be used alone or as an initial agent in patients in whom, in the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic. In the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic. In combination with other drugs, particularly a thiazide diuretic. In whom, in the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic. Propranolol exerts ant arrhythmic effects in concentrations producing beta-adrenergic blockade, which appears to be its principal ant arrhythmic mechanism of action. Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen.